- Jared A. Abell Papers, 23 December 1862-5 June 1864
- Broadside for G.W. Aimar's Neurotic Oil, etc. [18uu]
- Letter, November 1866, "Annie" to Charlotte C. Barnwell
- The Three Tickets, 20 July 1854, [short story] by Helen Barnwell
- Bonham Family Bible Records
- A.W. Brockway Logbook, 8 December 1896-7 April 1897
- Rev. Henry DeSaussure Bull Papers, 1911-1946
- Letter, 22 November 1930, from Erskine Caldwell to Leonardo Andrea
- Papers of the Coker and Stout Families, 1785-1919
- Letter, 19 April 1847, Andrew Cornish to John Hamilton Cornish
- Carwile Cox account book, 1869-1887, 1896
- Edith Mitchell Dabbs Papers, 1862-1991 [Addition]
- Letter, 28 December 1840, Mary Stanley Bunce Dana to the Rev. Artemus Bullard
- Letter, 7 September 1832, Phoebe Elliott to Charles Cotesworth Pinckney, Jr.
- Carlisle Floyd Papers, 1946-2000 [Addition]
- Foot Point Land Company Ledger, 1864-1866 and 1877
- William Crosland Frierson Papers, 1934-1968
- Labor Contract, 4 January 1866, with John H. Furman
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- Letter, 24 October 1834, William Gates to Brig. Gen. Roger Jones
- Lt. Daniel S. Hardenburg Papers, 27 November 1862-25 April 1865 and undated
- Jacob Bond I'on Account Book, 1850-1871
- Papers of the Janney-Leaphart Families, 1859-1897 [Addition]
- Lexington Medical Center Research Files, 1966-1990
- Lucy Williams McCaughrin Papers, 1873-1998
- Thomas Gordon and Elizabeth Alford McLeod Papers, 1845-2001
- Letter, 4 November 1837, Samuel E. Maxwell to Patrick Calhoun
- Richter Herman Moore Papers, 1873-1972
- Harry Stoll Mustard, Jr. Papers, 10 January 1944-23 October 1945
- James Drayton Nance Papers, 1860-1866, 1883, 1912, and undated [Addition]
- Dr. John Thompson Norris Papers, 1854-1881
- Letter, [ca. 1930], Louise Harllee Pearse to Louise Sallenger
- Duane C. Potter Papers, 10 September 1863-30 May 1866
- Affidavit, 1905-1914, on Behalf of F.W. Scheper
- Albert Taylor Scroggins Papers, 1931-2001
- Records, 10 May 1864-25 July 1870 of the United States Colored Troops, 26th Regiment
- Thomas M. Vise Papers, 1845-1917
- George Edward Walker Papers, 1846-1858 and 1861
- Colleton County Records and Papers of R.A. Willis, 1803-1837, 1871-1888
- Alice Norwood Spearman Wright Papers, 1923-1989 [Addition]
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